The challenge of analyzing real-world data lies in the disorganized nature of the data involved. Real-world evidence is derived from a variety of disparate sources which need to be suitably aligned to enable meaningful information to be extracted. Unlike RCTs, where the nature and method of data collection is outlined at the outset, real-world data is collected in a more ad hoc fashion often with great variability in how, when and what is recorded even within a single data source. This makes it difficult to extract reliable information. Read more here.